The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
- CSF titers of 1:4 or less are presumptive evidence of central nervous system infection by C. neoformans, additional follow-up and culture are strongly recommended. CSF titers of 1:8 or greater from patients with meningitis strongly suggest infection by C. neoformans. However, diagnosis should be confirmed by identification of the organism from culture or by microscopic examination of the specimen.
- A negative test does not preclude diagnosis of cryptococcosis, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis.
- A false positive reaction due to the antigen of Trichosporon beigelii which cross reacts with the C. neoformans capsular polysaccharide had been reported.
- High protein levels can cause interference.