Combined serum and urine antigen testing is more effective than urine testing alone. Antigen testing for both serum AND urine provides the highest sensitivity for histoplasmosis diagnosis. Urine can be antigen negative in patients with disseminated or diffuse pulmonary histoplasmosis.
Learn about the MiraVista Diagnostics MVista® Histoplasma Quantitative Ag EIA and the benefits of incorporating Histo Ag testing into your diagnostic protocol for histoplasmosis.
Urine may test negative for histoplasma antigen, and serum may be positive.
A patient with ulcerative colitis treated with TNF blocker therapy presented with respiratory symptoms but denied fever or weight loss. CT chest scans showed numerous parenchymal and pleural-based nodules with extensive mediastinal and bilateral hilar adenopathy. The urine tested negative for histoplasma antigen, but the serum antigen tested positive (2.89 µg/ml) using the MVista Histoplasma Galactomannan Antigen. [Test developed and performed at MiraVista Diagnostics]
Accurate diagnosis and treatment are critical to prevent hospitalization and mortality especially in immunocompromised patients.
Download MiraVista Diagnostics’ full briefing on Co-Testing Serum & Urine Antigen for Improved Histoplasmosis Diagnosis.