COCCIDIOIDES ANTIBODY IMMUNODIFFUSION

320

86635 x2

Pneumocystis cannot be cultured in vitro and has classically been diagnosed based upon clinical symptoms and radiographic findings with confirmation via microscopic visualization of stained organisms which has lower sensitivity that is reliant upon reader expertise. This polymerase chain reaction assay can provide rapid and specific detection and differentiation of Histoplasma capsulatum directly from clinical specimens.

Fungal Immunodiffusion

The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

• Cross-reactions can occur with Histoplasma capsulatum.
• False positive anti-Coccidioides TP band results may occur in patients diagnosed with Cystic Fibrosis.

Serum/Plasma: Separated from the clot in a leak-proof conatiner.

CSF: Sterile leak-proof container.

Serum/Plasma*/CSF*: 0.25 mL per antibody

* Reported with rare specimen comment applied.

• Refrigerated: 3 days
• Frozen: indefinite

Any specimen types other than serum, plasma, or CSF.

Refrigerated/Frozen

Ship on dry ice to arrive Monday‐Friday using a next day delivery service. Frozen ice packs may be substituted if sample is shipped the day of collection.

2 days from set up date.

• Antibody not detected
• Will report F and TP specific

• Negative: Antibody not detected
• Positive: Antibody detected, will report titer up to ≥1:128

• Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection, but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
• Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.