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Antibody Detection

ASPERGILLUS ANTIBODY IMMUNODIFFUSION

  • Test Code

    324

  • CPT Code

    86606

  • Clinical Significance

    The aspergillus antibody immunodiffusion test is used for the in vitro determination of precipitating antibodies to Aspergillus sp. It is also used as an aid in the diagnosis of Aspergillosis. Aspergillus antigen is represented by one or more precipitin bands and is indicative of infection, colonization or allergy to an Aspergillus sp. Generally speaking, the greater the number of precipitin bands the higher the probability of infection caused by a member of this genus.

  • Methodology

    Fungal Immunodiffusion

  • Limitations

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    • False positive results may occur in patients with inflammatory disease.
    • False negative results may occur in patients receiving long-term antifungal or corticosteroid therapy.
  • Specimen Collection

    Serum/Plasma: Separated from the clot in a leak-proof conatiner.

    CSF: Sterile leak-proof container.

  • Minimum Specimen Requirements

    Serum/Plasma*/CSF*: 0.25 mL per antibody

    * Reported with rare specimen comment applied.

  • Specimen Stability
    • Refrigerated: 3 days
    • Frozen: indefinite
  • Specimen Rejection

    Any specimen types other than serum, plasma, or CSF.

  • Transport Temperature

    Refrigerated/Frozen

  • Shipping

    Ship on dry ice to arrive Monday‐Friday using a next day delivery service. Frozen ice packs may be substituted if sample is shipped the day of collection.

  • Turnaround Time

    2 days from set up date.

  • Reference Range

    Antibody not detected.

  • Interpretative Information
    • Negative: Antibody not detected
    • Positive: Antibody detected

* New positives may require confirmation.

** Turnaround times are provided as ranges, and may vary depending on daily testing volumes and specimen type.

*** Test set up: Samples received by 10:30AM will have same-day test set up. Positive samples may require confirmation which may extend turnaround time. Serum & CSF specimens are pretreated to improve sensitivity which can add one day to turnaround time.

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