HISTOPLASMA ANTIBODY IMMUNODIFFUSION
-
Test Code
321
-
CPT Code
86698
-
Clinical Significance
The histoplasma antibody immunodiffusion test is used for the in vitro determination of precipitating antibodies to Histoplasma sp. It is also used as an aid in the diagnosis of Histoplasmosis. This test detects the presence of two significant precipitin bands. Presence of both the H and the M band indicates active histoplasmosis. The presence of the M band alone indicates early or chronic disease. The M band may also be present following a recent histoplasmin skin test.
-
Methodology
Fungal Immunodiffusion
-
Limitations
The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
- No cross-reactions or interfering substances were identified.
-
Specimen Collection
Serum/Plasma: Separated from the clot in a leak-proof conatiner.
CSF: Sterile leak-proof container.
-
Minimum Specimen Requirements
Serum/Plasma*/CSF*: 0.25 mL per antibody
* Reported with rare specimen comment applied.
-
Specimen Stability
- Refrigerated: 3 days
- Frozen: indefinite
-
Specimen Rejection
Any specimen types other than serum, plasma, or CSF.
-
Transport Temperature
Refrigerated/Frozen
-
Shipping
Ship on dry ice to arrive Monday‐Friday using a next day delivery service. Frozen ice packs may be substituted if sample is shipped the day of collection.
-
Turnaround Time
2 days from set up date.
-
Reference Range
- Antibody not detected
- Will report H and M bands
-
Interpretative Information
- Negative: Antibody not detected
- Positive: Antibody detected
* New positives may require confirmation.
** Turnaround times are provided as ranges, and may vary depending on daily testing volumes and specimen type.
*** Test set up: Samples received by 10:30AM will have same-day test set up. Positive samples may require confirmation which may extend turnaround time. Serum & CSF specimens are pretreated to improve sensitivity which can add one day to turnaround time.