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Antigen Detection

COCCIDIOIDES QUANTITATIVE EIA TEST

  • Test Code

    315

  • CPT Code

    87449

  • Clinical Significance

    Antigen detection offers an advance in diagnosis in humans and complements serologic and mycologic tests for coccidioidomycosis. Antigen may be detected early in the course of infection, before the development of antibodies, and more quickly than traditional culture. Antigen detection tests offer faster results and are highly sensitive, especially in urine and blood samples of patients with dissemintated or pulmonary coccidioidomycosis.

  • Methodology
    • Quantitative Sandwich Enzyme Immunoassay (EIA)
    • Serum and CSF are pre-treated to improve accuracy
  • Limitations

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    • Cross-reactions are seen with histoplasmosis, blastomycosis and paracoccidioidomycosis.
    • Sputolysin, sodium hydroxide, and potassium hydroxide treatment degrade the analyte detected in the assay.
    • Low positive cross-reactions can occur in patient populations with Rheumatoid Arthritis.
  • Specimen Collection
    • Serum/Plasma: Separated from the clot, in a leak-proof container.
    • Urine/CSF/BAL/Other Body Fluid: Submit urine, CSF, BAL and all other body fluids in a sterile leak-proof container.
    • New York approved for Urine, Serum, EDTA Plasma, CSF, and BAL samples.
  • Minimum Specimen Requirements
    • All specimen: 0.8 mL
  • Specimen Stability
    • Room Temperature: 28 days
    • Refrigerated: 28 days
    • Frozen: 60 days
  • Specimen Rejection
    • Non-pipettable specimens, tissue, biopsy, sputum, bronchial brush, tracheal aspirate, FNA, bone marrow, aspirate or stool
    • Samples in transport media, fixative or Isolator tubes

    For specimen submissions that do not meet these criteria, please call Customer Service.

  • Transport Temperature

    Refrigerated/Frozen/Room Temperature

  • Shipping

    Ship next day service Monday- Saturday delivery

  • Turnaround Time

    Testing is performed Monday-Saturday

    • Urine/BAL: Same day
    • Serum/Plasma/CSF: 1 day

    *New positives may require confirmation

    **Test Set up: Samples for Antigen testing received by 10:30AM will have same day test set up. Positive samples may require confirmation which could extend TAT. Serum & CSF specimens are pretreated to improve sensitivity which can add one day to TAT.

     

  • Reference Range

    None detected

  • Interpretative Information
    • Positive: 0.07-8.2 ng/mL
    • Positive Above the Limit of Quantification: Results greater than 8.2 ng/mL fall outside the linear range of the assay. These results are positive, but not accurately quantifiable.
  • Additional Information

    MVista® is a registered trademark of MiraVista Diagnostics

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