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Antibody Detection

COCCIDIOIDES ANTIBODY IMMUNODIFFUSION

  • Test Code

    320

  • CPT Code

    86635 x2

  • Clinical Significance

    The coccidioides antibody immunodiffusion test is used for the in vitro determination of precipitating antibodies to Coccidioides TP and F antigens. It is also used as an aid in the diagnosis of Coccidioidomycosis.

  • Methodology

    Fungal Immunodiffusion

  • Limitations

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    • Negative serologic tests may be observed among culturally demonstrable cases, which limits the predictive value of a negative test.
    • Negative serologic results obtained during the first month may warrant repeat testing.
    • Falsely negative results may be obtained when testing immunocompromised patients.
    • Test results cannot be used solely to distinguish between active infection and prior exposure.
  • Specimen Collection

    Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.

  • Minimum Specimen Requirements

    Serum: 0.25 mL per antibody

  • Specimen Stability
    • Refrigerated: 14 days
    • Frozen: 6 months
  • Specimen Rejection

    Any specimen types other than serum.

  • Transport Temperature

    Refrigerated/Frozen

  • Shipping

    Ship on dry ice to arrive Monday‐Friday using a next day delivery service. Frozen ice packs may be substituted if sample is shipped the day of collection.

  • Turnaround Time

    Testing performed Tuesdays and Fridays.

    Serum: TAT 72 hours from setup

  • Reference Range
    • Antibody not detected
    • Will report F and TP specific
  • Interpretative Information
    • Negative: Antibody not detected
    • Positive: Antibody detected, will report titer up to ≥1:128
  • Additional Information
    • Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection, but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
    • Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.
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