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Clinical Resources

In Vitro Activity of Isavuconazole Against Fluconazole-Resistant Isolates of Histoplasma Capsulatum

QUESTION: Which triazoles are effective alternatives to itraconazole for treatment of histoplasmosis? ANSWER: Evidence suggests that fluconazole is not adequate. Information about the other triazoles is insufficient to make an evidence-based choice. However, posaconazole appears to be the best alternative….
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Noninvasive Diagnosis of Central Nervous System Blastomycosis

QUESTION: What do you think is the most sensitive test for diagnosis? Culture Pathology Molecular Antigen detection Antibody detection ANSWER: A recently published case report and literature review provides insight into the diagnostic approach, which we have supplemented with literature…
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Nonculture Diagnosis of Central Nervous System Coccidioidomycosis

A previously healthy young man from California presented with a one-month history of headache and intermittent fever. Physical examination was unremarkable. CSF contained 123 leukocytes/µl, 72% mononuclear cells. Protein was 103 mg/dl and glucose 26 mg/dl. No organisms were seen…
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