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Clinical Resources

Accuracy of the MVista® Histoplasma Antibody IgG, IgM Immunoassay to Evaluate Suspicious Lung Nodules

Endemic mycoticdiseases (histoplasmosis, blastomycosis, coccidioidomycosis) are common causes of lung granulomas. They present diagnostic challenges when there is radiographic evidence of indeterminate pulmonary nodules (IPN) which are well defined nodules less than 1 centimeter in diameter, especially when found on…
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An Interesting Case

QUESTION: Which triazoles are effective alternatives to itraconazole for treatment of histoplasmosis? ANSWER: Evidence suggests that fluconazole is not adequate. Information about the other triazoles is insufficient to make an evidence-based choice. However, posaconazole appears to be the best alternative….
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Noninvasive Diagnosis of Central Nervous System Blastomycosis

QUESTION: What do you think is the most sensitive test for diagnosis? Culture Pathology Molecular Antigen detection Antibody detection ANSWER: A recently published case report and literature review provides insight into the diagnostic approach, which we have supplemented with literature…
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Nonculture Diagnosis of Central Nervous System Coccidioidomycosis

A previously healthy young man from California presented with a one-month history of headache and intermittent fever. Physical examination was unremarkable. CSF contained 123 leukocytes/µl, 72% mononuclear cells. Protein was 103 mg/dl and glucose 26 mg/dl. No organisms were seen…
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